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Once you develop a nickel allergy, however, you'll always be sensitive to the metal and need to avoid contact." Mayo Clinic Bottom line People who are allergic to B 12 are reacting to the presence of cobalt – a metal similar to nickel nickel, which is a known allergen

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Several topics require future in-depth investigations, such as the clinical benefit of using prophylactic B12 supplementation in some groups who are at risk of B12 deficiency due to accompanying diseases or medications