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[ ] Comparing gene expression in these tumors with those observed in different liver zones of healthy mice, they proposed that β‐catenin produced by central vein endothelial cells regulates pericentral gene expression, whereas periportal gene expression is determined by Ras signaling, induced by bloodborne molecules arriving through the portal vein

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The activation of these kinases results in the phosphorylation of IRS1 on serine 307 resulting in inhibition of the insulin-stimulated tyrosine phosphorylation of IRS1 leading to inhibition of insulin signaling