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However, the class II enzymes attach to the peroxisomal membrane and have essential roles in plant development (Eastmond, 2007)
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FSP1 dependency is not mutation-specific To more thoroughly interrogate the functional importance of Fsp1 for tumorigenesis and the translational potential for targeting Fsp1 in cancer, we assessed the requirement of FSP1 for growth of xenograft tumors from human LUAD cell lines harboring a variety of driver mutations, including KRAS, NRAS, EGFR, TP53, STK11 and KEAP1
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