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A proposal molecular mechanism model of mycotoxin exposure-induced cell... | Download Scientific Diagram

NO derived from endothelial cells inhibits platelet aggregation, prevents thrombus formation and regulates the expression of genes associated with atherosclerosis (AS), thereby blocking leukocyte adhesion and migration to the endothelium, which helps prevent AS progression (13,14)

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Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is “normal” In other words, chronic injuries do not usually need one intervention