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Only 40.9% of participants reached the MCID of ≥4 points, as defined by Rosen et al
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The 2026 Evidence for Kisspeptin in PMOS A landmark 2024 pre-clinical study published in Human Reproduction found that targeted inhibition of ARC kisspeptin-expressing neurons in a mouse model of PMOS lowered LH pulse frequency and restored normal androgen concentrations
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