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The anorexia associated with cancer cachexia is likely caused by the activity of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) and growth differentiation factor 15, that are produced either by the tumor or by the host in response to the tumor, which interfere with appetite signals within the anterior hypothalamus ( Undernutrition is a common problem in patients with cancer cachexia and can be a consequence of both reduced dietary intake, poor dietary quality and hypermetabolism ( For a long time, undernutrition and cachexia remained neglected medical conditions for which a clear therapeutic strategy was lacking
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