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Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention

However, serum B12 levels may not accurately reflect cellular B12 status or functional deficiency at the tissue level

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The most common genetic causes include: family history of PCT inherited deficiency of the liver enzyme uroporphyrinogen decarboxylase (UROD) family history of liver disease or liver cancer high levels of iron in the liver The most common acquired causes include: excess alcohol consumption estrogen therapy oral contraceptives excess iron smoking hepatitis C HIV You may have a higher risk of PCT if you smoke or use alcohol

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