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In an animal study, inhibition of the NF-κB pathway led to a significant reduction in the expression of serum proinflammatory cytokines, including IL-6, IL-1β and TNF-α, as well as an increase in the expression of the tight junction proteins occludin and ZO-1, thereby improving the function and structure of the intestinal mucosa
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Iron overload resulted in impaired cardiac relaxation as evident from (i) an increase in isovolumic relaxation time (IVRT), (ii) an increase in deceleration time (DT), and (iii) a decrease in the ratio of annular velocities ( E ′/ A ′) (Figure 2D)
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