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The role of CAT versus peroxynitrite has been much debated, but recent advances suggested CAT’s ability to scavenge ONOO – (Gebicka and Didik, 2009)
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These results underscore that methionine metabolism, specifically SAM biosynthesis, plays a critical role in cancer stem cell survival, although the functional role of these epigenetic alterations in the observed effects of methionine deprivation on cancer stem cells has not been delineated
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