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IR may be responsible for high blood pressure via direct stimulation of renin–angiotensin–aldosterone system (Nickenig et al., 1998), activation of sympathetic system (Sowers et al., 2001) and downregulation of the natriuretic peptide system (Sarzani et al., 1999)

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Data from participating countries indicate increasing circulation of illicit anti-diabetic medicines globally due to their off-label weight loss effects, with unapproved and potentially fake drugs seized in the Asia-Pacific, Europe and North America