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The binding of IL2 to IL2R leads to phosphorylation, dimerization and translocation of STAT5 (signal transducer and activator of transcription 5) to the nucleus, where they direct the transcription of target genes required for the Treg immunosuppressive phenotype, largely through direct regulation of FOXP3 expression (81)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Marsh D

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