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4HNE also has a biphasic effect on tyrosine kinase receptor (RTK) signaling (Awasthi et al., 2005a) has also been shown to induce stress-responsive prosurvival factors, such as Nrf2, HSF1 and its client heat shock proteins, EGFR, and the transcription repressor Daxx, which can inhibit Fas-mediated apoptosis (Sharma et al., 2008a
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