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Tregs producing IL-35 accumulated in the TME and impeded effector T cell activation and their effector function by inducing the expression of several inhibitory receptors such as PD-1 (Programmed cell death protein 1), Tim-3(T cell immunoglobulin and mucin-3)and BLIMP1(B-lymphocyte-induced maturation protein-1)-dependent exhaustion (32)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 355.Agraib L.M., Yamani M.I., Tayyem R., Abu-Sneineh A.T., Rayyan Y.M
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