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The gut microenvironment, with its diverse array of antigens, commensal bacteria, and metabolites, provides stimuli that promote the differentiation of naïve T-cell into iTreg cells

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Although early NAC treatment is beneficial in limiting the injury, continuous NAC treatment well beyond the injury phase can delay regeneration [72] mainly through impairment of mitochondrial biogenesis, an adaptive response whose role is to maintain or restore homeostasis following mitochondrial dysfunction [71]