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The management of patients include patient-reported outcomes for long-term follow-up care and for early detection of possible adverse events and the use of digital technologies, such as telemedicine - videoconferences for patients’ follow-up and reinfection risk elimination, digital therapeutics approach, especially for non-pharmaceutical interventions (e.g., breathing exercises), electronic control of body parameters such as temperature, oxygen saturation, blood pressure, that can be measured with wearable devices and the data can be analyzed with artificial intelligence (256, 257)

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Likewise, in a recent trial in which participants were randomly assigned, neither they nor the researchers knew who was receiving the treatment and who was receiving the placebo found that administering 1 mg of oral methylcobalamin to individuals with nerve damage due to diabetes treated with metformin for twelve months resulted in enhanced plasma levels of B12 and alleviation of neurophysiological symptoms [53]