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Despite great efforts put into evaluating bulls using BSE, bull fertility is deemed suboptimal under field conditions, with a conception rate varying from 20 to 40% ( Genome-wide association studies (GWAS) have been effective in applying dense genetic markers, such as single-nucleotide polymorphism (SNP) markers, to determine genomic regions associated with economically important phenotype such as fertility (Table 1)

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This nootropic effect derived from its N-terminal region given that tetra- and tripeptide fragments of Nle 1 -AngIV were also capable of overcoming scopolamine-induced amnesia [70-72]