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These infiltrating immune cells, in concert with fibroblast-like synoviocytes (FLS) and resident macrophages, promote chronic inflammation and stimulate the release of ECM-degrading enzymes and key factors such as receptor activator of NF-κB ligand (RANKL), which enhance osteoclast differentiation and activity (192)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Pergola P.E., Raskin P., Toto R.D., Meyer C.J., Huff J.W., Grossman E.B., Krauth M., Ruiz S., Audhya P., Christ-Schmidt H., et al