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For instance, genes that encode critical antioxidant enzymes, including glutathione (GSH)/glutathione peroxidase 4 (GPX4), coenzyme Q10 (CoQ10)/ferroptosis suppressor protein 1 (FSP1), 22 nuclear factor erythroid 2-like 2 (Nrf2), dihydroorotate dehydrogenase (DHODH) 33,34 and genes involved in lipid metabolism, such as acyl-CoA synthetase long-chain family member 4 (ACSL4), and genes encoding proteins in related pathways are considered to be specific suppressors or drivers of ferroptosis
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