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Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex - ScienceDirect

This seems to be a reasonable interpretation, since further studies using GSTP knockout (GSTP KO) mice and the general GST inhibitor ketoprofen found that both genetic knockout and pharmacological inhibition resulted in an increase in cocaine sensitization as measured by locomotor activity, while GSTP KO also showed an increase in conditioned place preference [38]

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The latter mechanisms demonstrate that Nrf2, as a master transcription factor of oxidative stress, functions redundantly in activating the antioxidant machinery through multiple pathways, thereby reducing oxidative stress