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Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer | Molecular Cancer | Springer Nature Link

GHK-Cu (glycyl-L-histidyl-L-lysine:Cu²⁺) acts through a fundamentally different receptor/signal transduction mechanism: TGF-β1-Smad2/3 (collagen synthesis), Nrf2-ARE (antioxidant defence), EGF receptor transactivation (keratinocyte proliferation) and direct extracellular matrix metalloprotease modulation (MMP-1/TIMP-1 balance)

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Host genetic background, early-life microbial colonization, dietary habits, smoking, alcohol intake, antibiotic and proton-pump inhibitor use, and underlying disease conditions can all contribute to gut microbiota dysbiosis ( 3.1 Disruption of the intestinal barrier The normal gut microbiota plays a vital role in preserving the structural and functional integrity of the intestinal mucosa