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The second is ignoring the volume the solid itself occupies — small at these masses, but not zero, and it means the final volume is very slightly greater than the volume you added
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This may result from a shift in the immunodominant epitopes on the spike protein of the Beta variant, as antibodies raised to Beta were more focused on epitopes outside of the ACE2-binding site that recognize RBD in both ‘up’ and ‘down’ conformations, analogous to the S309 monoclonal antibody 112,115,116,117
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