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Indeed, copper can be found at the active site of many critical enzymes, including those essential for neurological function, such as the predominantly cytosolically localized antioxidant Cu, Zn superoxide dismutase (SOD1), the mitochondrial electron transport chain protein cytochrome c oxidase, and the secretory pathway enzymes dopamine β -hydroxylase (DBH) and peptidylglycine α -amidating monooxygenase (PAM) (Scheiber et al., 2014)
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