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The turnover of ECM proteins is enzymatically regulated by ECM proteases, degrading enzymes belonging to the metzincin family, including matrix metalloproteinases (MMPs), \(\alpha\)-disintegrin and metalloproteinases (ADAMs) and \(\alpha\)-disintegrin and metalloproteinases with thrombospondin motifs (ADAMTSs) [23]
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It suggests that the instrument underestimates the measured signal on one day, but overestimates on another
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