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However, modest increases in ROS levels above normal stimulate Nrf2-orchestrated adaptation to relatively low levels of oxidative stress, whereas higher increases in ROS stimulate nuclear factor-κB (NF-κB) along with AP-1 to provide a second tier of defense against more severe oxidative stress [187, 188]

tissue homeostasis

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Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy