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Noteworthy, at the border of bone tissue, there was a periosteum reaction and close contact with muscle fibers, and the proliferation of mesenchymal stem cells occurred (Figure 14 and Figure 15)

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When a patient on a stable transdermal estradiol regimen cannot fill her prescription because patches are on backorder, the prescriber faces a clinical decision: switch to an oral formulation (with a different risk profile), switch to a different delivery system the patient hasn’t used before, or consider a compounded transdermal estradiol preparation that delivers the same active ingredient through the same route