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The biology of ergothioneine, an antioxidant nutraceutical - PMC
425 Ras/Raf/MEK/ERK can be activated through distinct mechanisms: (1) a ligand-dependent route, where ligands, including hormones, growth factors, or cytokines, specifically bind to receptors and (2) a ligand-independent route, triggered by physical stressors like injury, radiation, or osmotic pressure
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