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Similarly, oral administration of L-cysteine has also been shown to have little effect on brain GSH levels owing to first-pass metabolism.8–10 Oral NAC administration results in increased plasma cysteine levels, ultimately leading to increases in plasma GSH.11,12 N -acetylcysteine has been shown to successfully penetrate the blood–brain barrier and raise brain GSH levels in animal models,13–15 which may be relevant to psychiatry, where alterations in brain GSH and other redox pathways have been shown