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Moreover, despite favorable in vitro performance, the long-term stability, degradation, metabolism, and immunological consequences of many surface modifiers remain insufficiently understood
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Recent CRISPR-Cas9 screens have identified multiple novel regulators of GPX4 expression and ferroptosis sensitivity, including NCOA4 (ferritinophagy receptor), NRF1 (a regulator of proteasomal genes), and KEAP1 (a repressor of Nrf2) [67]
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