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We demonstrate that melatonin-driven glutathione accumulation suppresses ILC2 effector cytokine production and ameliorates airway hyperreactivity and inflammation in multiple murine models of allergic airway disease
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The iron balance dual-drive strategy (IBDS) exemplifies this concept: Deferiprone-conjugated polyamidoamine dendrimer with triphenylphosphonium mitochondria-targeting moiety (DFP-PAMAM-TPP) nanoparticles not only chelate mitochondrial iron but also promote ferritin synthesis via P5CS-mediated pathways, thereby avoiding the toxicity associated with excessive chelation while maintaining physiological iron homeostasis (125)
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