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HRW may reduce the levels of TNF-α, IL-1β and IL-6 in HE rats through the following mechanisms, thereby alleviating the cognitive dysfunction of HE rats: (1) Antioxidant effect: Molecular hydrogen in HRW has a strong antioxidant capacity, which can clear excess ROS and inhibit the activation of pro-inflammatory signaling pathways such as nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) cascades, thus reducing the production of inflammatory factors, and the reduction of inflammatory factors can reduce the apoptosis and necrosis of neurons

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An increase in intestinal sodium absorption is also part of the increased sodium balance in hypertension, which may be related to increased activity of NHE3 and Na + -K + -ATPase [135, 136]