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This effect can increase sympathetic outflow and potentiate the release of norepinephrine from nerve endings, leading to activation of α1 and β1 receptors in the heart and peripheral vasculature, with a consequent rise in blood pressure Blocks presynaptic α2 adrenergic receptors Indications: Rarely used Sometimes used in the treatment of orthostatic hypotension because it promotes norepinephrine release through blockade of α2 receptors in both the central nervous system and the periphery There is some evidence that it may be “possibly effective” in treating erectile dysfunction & SSRI related sexual dysfunction in both men & women by unclear mechanisms (NIH Medlineplus) Has been suggested to have aphrodisiac properties Side Effects: Yohimbine exerts a stimulating action on the mood and may increase anxiety Major drug Interactions: Yohimbine can reverse the antihypertensive effects of an α2 receptor agonist such as clonidine, a potentially serious adverse drug interaction References: Biaggioni I (2021): Adrenoceptor Antagonists (Chapter 10)

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doi: 10.3390/biom9110649