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In the same context, impaired mitochondrial activity in NASH patients due to reduced enzymatic activities of mitochondrial electron transport chain and excessive in FA oxidation results in hepatic ATP depletion and may cause structural mitochondrial abnormalities consisting of enlargement (megamitochondria), paracrystalline inclusions, and loss of cristae [39,40]
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25 Besides, GSTP1 negatively regulates STAT3 activation in epidermal growth factor (EGF) signaling, and is also a regulator of the cell cycle via EGF signaling in human hepatocellular carcinoma (HCC)
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