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To validate this hypothesis, we compared the differentially expressed genes following BTN3A2 knockdown with the established DNA damage response (DDR) gene set derived from sequencing results, revealing a significant correlation between BTN3A2 knockdown and alterations in the expression of several critical DDR markers, including CDK2, RAD51, CHEK1, and CHAF1B
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However, careful consideration of timing and skin sensitivity is crucial
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