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Most of the studies on plant-based diets are epidemiological observation, which are invaluable in revealing associations at the population level but are inherently subject to confounding by other health-conscious behaviors such as regular exercise, non-smoking, preventive visits to doctors, and higher socioeconomic status, which co-occur with making plant-based choices in the cohorts, and there are also limitations in dietary assessment accuracy when relying on self-report instruments (112, 155)