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Mind the Anion Gap: 5-Oxoproline-Induced High Anion Gap Metabolic Acidosis in End-Stage Renal Disease - PMC

For instance, when intra-portal insulin levels are increased [e.g., obesity, Cushing’s syndrome or due to treatment with glucocorticoids and glucagon-like peptide-1 receptor agonists (GLP-1RA)] or decreased (e.g., anorexia nervosa and T1D) in disease states, these secondary changes (“secondary association”) alters hepatic GH sensitivity resulting in discordant GH and IGF-I levels (high GH/low IGF-I levels and low GH/high IGF-I levels, respectively)

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This is confirmed by the physical and numerically-predicted signals from the sagittal rows demonstrating relatively lower correlation coefficients (when contrasted with the correlations for the signals from the sagittal and front columns) in the two experimental comparisons (e.g