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227,229 In AD, autophagy defects mediate the disruption of protein homeostasis networks (production and extracellular secretion of Aβ, abnormal aggregation of tau protein) and lead to the accumulation of damaged organelles, such as dysfunctional mitochondria

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The rate of recurrence was 28 % after reinitiating ATRA.72 In 240 APL patients from the Intergroup Protocol 0129 (I0129), probable PTC occurred in 1.7 % of patients (ages: 4–24 years old) who received ATRA 45 mg/m2/day during induction or maintenance