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Full article: Ergothioneine: Evaluation of a Novel Antioxidant for Targeting Ocular Oxidative Stress
Beyond GPX4’s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycle—involving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin export—to conserve iron and prevent its urinary loss (119)
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antibiotic-sensitive bacteria, those metabolites are likely candidates for use as metabolic reprogramming agents
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