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It is still debated whether Gd 3+ blocks ion channels of different nature as a result of the ion binding to specific proteins or due to incorporation of Gd 3+ into the lipid bilayer, which, in turn, results in major structural changes in the membrane in the vicinity of the ionic channels

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Continuing to the formation of the second core, the evolution of the first core was similar with frequency-dependent models to the grey models (Vaytet et al., 2013)