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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more β-galactosidase-positive cells in keloids

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BPC-157 is an exception because it is not an exogenous peptide being introduced into a foreign environment: it is a peptide found naturally in human gastric juice at low concentrations, where it appears to serve a mucosal protective function