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Numerous studies have demonstrated that curcumin not only reshapes the gut microbiota structure in HFD and diabetic animal models by increasing beneficial bacteria such as Akkermansia , Bifidobacterium , and Lactobacillus while suppressing endotoxin-producing bacteria like Enterobacteriaceae and Desulfovibrio , but also enhances intestinal barrier integrity by promoting the expression of ZO-1 and occludin

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Studies showed that curcumin treatment significantly enhanced SOD activity, reduced and MDA levels, and offset the DOX-induced decline in AKT and mTOR phosphorylation levels, partially reversing the NLRP3 inflammator-mediated changes in pyrogenic protein markers