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Metabotropic Glutamate Receptors (mGluRs) mGluRs, particularly mGluR1 and mGluR5, are G-protein-coupled receptors that modulate excitatory neurotransmission, synaptic plasticity, and intracellular signaling cascades through activation of phospholipase C (PLC) and the resulting production of inositol trisphosphate (IP 3 ) and diacylglycerol (DAG), ultimately leading to calcium release from intracellular stores and activation of protein kinase C (PKC)
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