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On the one hand, Glu can be polymerized with cysteine in an ATP-dependent manner to form γ-glutamylcysteine, and further condense with glycine to produce GSH ( via cystine/glutamate antiporter xCT (also commonly known as SLC7A11) to the extracellular for exchanging cystine and a subsequent conversion of cystine to cysteine through a NADPH-consuming reduction reaction
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