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Clinical models are useful for understanding how the BBB is functioning and disrupted in patients with disease, however drugs and therapeutics are not screened in clinical models until there is some certainty using in vivo and models that the therapeutic is safe and effective
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BoNTs are dichain toxins composed of a light chain protease and a heavy chain, which is further divided into two functional domains: an N-terminal translocation domain (H N ) and a C-terminal receptor-binding domain (H C ) 21
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