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The neurological symptoms of COVID-19 likely originate from SARS-CoV-2 infection of the olfactory epithelium expressing ACE2 receptor that leads to anosmia, as well as from the virus-induced neuroinflammation and oxidative stress damaging biomolecules in the cells including neurons that cause headaches, depression, cognitive impairments, or “brain fog” [39]

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Although great attention has been directed to the mitochondria for their role in ATP production via oxidative phosphorylation, less discussed is the role that functional mitochondria serve in promoting health through redox homeostasis and mitigation of OS and inflammation [84]