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Manganese, at higher levels, causes the glutamate transporters to be localized into the cytosol, resulting in higher glutamate levels in the synapse.[ref] Related article : Manganese, genetics, diet, and supplements Kainic acid is another EAAT2 inhibitor that increases glutamate in the synapse.[ref] Kainic acid is found in nature only in certain types of seaweed and is unlikely to be eaten
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