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The dynamic and reversible post-translational protein modification usually on Ser/Thr residues are responsible in cellular signaling, alteration of transcription factors, cofactors in adipocytes, muscle cells, and pancreatic β-cells, which may alter gene expression leading to diabetic complications
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The apoptotic cells were estimated by the percentage of cells that stained positive for Annexin V-FITC while remaining impermeable to PI (AV+/PI−)
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