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Table 1: Proposed Mechanisms at a Glance Researchers Sikiric and colleagues, in a 2025 paper published in Pharmaceuticals , described BPC-157’s proposed activity as centered on a pleiotropic beneficial effect that controls and modulates angiogenesis and the nitric oxide system, and argued that the compound has demonstrated high safety in animal models, with no lethal dose (LD1) identified — a claim that remains debated among other researchers, since animal safety data doesn’t automatically translate to confirmed human safety