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In case of significant hemorrhage: hypovolemic shock [10] Diagnostics [10] Laboratory studies Urine or serum β-hCG: obtain in all patients to exclude intrauterine or ectopic pregnancy CBC: may show anemia Emergency preoperative diagnostics: coagulation panel, type and screen Imaging POCUS/FAST: Consider in unstable patients to rapidly assess for the presence and extent of free fluid

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Practical readouts to separate signalling from damage Practical readouts to separate signalling from damage combine signalling proxies—such as reversible cysteine oxidation mapped by redox proteomics, the redox state of peroxiredoxins as fast cycling sentinels, compartment-targeted H 2 O 2 reporters that resolve matrix/ER/PM microdomains and phospho-signatures downstream of redox-sensitive kinases—with damage proxies including lipid-peroxidation adducts, protein carbonyls or nitrotyrosine, DNA oxidation and strand breaks and indices of bioenergetic failure (Garrido Ruiz et al