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In addition to its role as an amino acid in protein biosynthesis and as a precursor for the synthesis of NAD + , tryptophan also serves as a precursor for the synthesis of the neurotransmitters serotonin and melatonin
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Calreticulin (CRT), a soluble chaperone associated with the endoplasmic reticulum (ER), is one of the proteins that regulates the tumor microenvironment
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