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J Formos Med Assoc (2009) 108:337–43.10.1016/S0929-6646(09)60075-9 111 TsilchorozidouTVagropoulosIKaragianidouCGrigoriadisN
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The potential metabolism-immune-neuro interaction framework of PEM is based on multi-level molecular crosstalk: mitochondrial dysfunction generates DAMPs that activate innate immune pathways (NLRP3, NF-κB) to induce peripheral inflammation
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